反应 #49089
ord-e9b1ab97345d4dc9918fcfef0393f96d
反应方程式
反应条件
详细条件
See reaction.notes.procedure_details.
后处理
- 1萃取After 6 days the reaction mixture was extracted with ethyl acetate
- 2洗涤washed with sodium bicarbonate solution
- 3干燥dried (Na2SO4)
- 4其他evaporated in vacuo
实验过程
To an ice-cooled suspension of dibenzylamine hydrochloride (13.5 g; 0.058 mol) and cyclopentanone (4.86 g; 0.058 mol) in 25% ethanol in water (100 ml) was added ethanol (60 ml) and a solution of potassium cyanide (3.78 g; 0.058 mol) in water (35 ml) dropwise over 20 minutes with stirring. After 6 days the reaction mixture was extracted with ethyl acetate, washed with sodium bicarbonate solution, dried (Na2SO4) and evaporated in vacuo to afford the title compound as an off white solid (8.32 g, 49%). 1H NMR (CDCl3) δ: 1.72 (6H, m), 2.12 (2H, m), 3.78 (4H, m), 7.1-7.3 (10H, m); Mass Spectrum (Electrospray LC/MS): Found 264 (MH+−HCN). C20H22N2 requires 290. Ret. time 1.88 min.