反应 #49072

反应方程式

D1

1-(dimethylamino)cyclopentanecarbonitrile

azetidine hydrochloride

cyclopentanone

potassium cyanide

→

title compound

收率 43.0%

1-(1-Azetidinyl)cyclopentanecarbonitrile

收率 43.0%

溶剂

water

反应条件

实验过程

The title compound (1.29 g, 43%) was prepared from azetidine hydrochloride (1.85 g, 20 mmol), cyclopentanone (1.68 g, 20 mmol) and potassium cyanide (1.30 g, 20 mmol) in water (10 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.70-1.82 (6H, m), 1.86 (2H, m), 2.07 (2H, quin, J=7 Hz), 3.32 (4H, t, J=7 Hz).

来源