反应 #48920

反应方程式

4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one

Selectfluor

→

4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one

溶剂

acetonitrile

反应条件

后处理

1. 1
   浓缩concentrated
2. 2
   其他purified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate)

实验过程

A mixture of 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one (100 mg, 0.36 mmol, Example 3, Step 1), Selectfluor (160 mg, 0.45 mmol), and acetonitrile (1.5 mL) were stirred vigorously for 18 h, concentrated, and then purified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate) to give 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one: MS (ESI): 294.0.

来源