反应 #487112

反应方程式

ethyl chloride

sodium methoxide

N-hydroxytetra-hydrophthalimide

ethyl chloride

water

→

N-ethoxytetra-hydrophthalimide

收率 74.2%

溶剂

methanol

反应条件

后处理

1. 1
   其他was held at 100° C
2. 2
   萃取the whole was afterwards extracted with toluene
3. 3
   其他to obtain the product
4. 4
   萃取Gas chromatographic analysis of the toluene extract

实验过程

In an autoclave a solution of 3.5 g of sodium methoxide (0.065 mol) in 40 ml of methanol, 11.0 g of N-hydroxytetra-hydrophthalimide (0.066 mol) and 4.6 g (0.072 mol) of ethyl chloride were mixed together. The mixture was heated to 100° C. After reaching this temperature the mixture was stirred for a further 5 hours while the temperature was held at 100° C. After 5 hours' reaction the excess ethyl chloride was blown out and the reaction mixture was discharged. The reaction mixture comprised a large quantity of solid material. This was dissolved by the addition of water and the whole was afterwards extracted with toluene to obtain the product. Gas chromatographic analysis of the toluene extract showed that the yield was 74% of N-ethoxytetra-hydrophthalimide (0.049 mol).

来源