反应 #48592

反应方程式

4-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

lithium hydroxide monohydrate

→

4-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid

收率 108.1%

溶剂

THF water

反应条件

后处理

1. 1
   其他The THF was removed by evaporation
2. 2
   萃取then extracted with ethyl acetate (20 ml)
3. 3
   干燥The ethyl acetate layer was dried (MgSC4)
4. 4
   过滤filtered
5. 5
   其他evaporated

实验过程

A solution of 4-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (205 mg; 0.72 mmol) and lithium hydroxide monohydrate (125 mg; 2.9 mmol) in 1:1 THF/water (10 ml) was heated at 60° C. overnight. The THF was removed by evaporation, the aqueous phase acidified with 1M hydrochloric acid then extracted with ethyl acetate (20 ml). The ethyl acetate layer was dried (MgSC4), filtered and evaporated to give 200 mg of 4-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid. (LC/MS: [M+H]+ 256.85).

来源