反应 #48567

反应方程式

4-amino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide

cyclohexanone

sodium triacetoxyborohydride

→

product

收率 15.9%

4-Cyclohexylamino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide

收率 15.9%

溶剂

dichloromethane

反应条件

后处理

1. 1
   过滤The reaction mixture was filtered through Celite®
2. 2
   workup.ADDITIONdiluted with ethyl acetate
3. 3
   洗涤washed with brine
4. 4
   干燥dried (MgSO4)
5. 5
   其他evaporated

实验过程

To a solution of 4-amino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide (200 mg; 1 mmol) and cyclohexanone (107 mg; 1.1 mmol) in dichloromethane (10 ml) were added 3 Å molecular sieves (1 g) and sodium triacetoxyborohydride (315 mg; 1.5 mmol), and the mixture was then stirred at room temperature over the weekend. The reaction mixture was filtered through Celite®, diluted with ethyl acetate, washed with brine, dried (MgSO4) and evaporated to give the 48 mg of the product as a grey gum. (LC/MS: Rt 2.95, [M+H]+ 285).

来源