反应 #4856

反应方程式

2-(2-amino-3,5-dinitrophenyl)ethanol

sodium sulphide nonahydrate

sulphur

→

expected product

2-(2,3-diamino-5-nitrophenyl)ethanol

溶剂

isopropanol

water

water

反应条件

后处理

1. 1
   workup.ADDITIONhas been added
2. 2
   温度Heating
3. 3
   温度is maintained for 20 minutes
4. 4
   workup.ADDITIONafter the addition
5. 5
   温度When the mixture is cooled

实验过程

To a suspension of 0.119 mole (27 g) of 2-(2-amino-3,5-dinitrophenyl)ethanol obtained in Example 1 in 67.5 ml of isopropanol to which an equal volume of water has been added, a solutionof 38.4 g of sodium sulphide nonahydrate and 5.4 g of sulphur in 10 ml of water is added dropwise at 60°-65° C. Heating is maintained for 20 minutes after the addition is complete. When the mixture is cooled, a precipitate of the expected product is obtained, and this is drained, made into a paste in water and then recrystallized from 96° strength alcohol. It melts at 172° C.

来源