反应 #48416

反应方程式

sodium carbonate

Sodium periodate

tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-1-[2-(methylthio)ethyl]-2-oxoazepan-3-ylcarbamate

sodium periodate

→

title compound

tert-Butyl (3R,6S)-6-(2,3-difluorophenyl)-1-[2-(methylsulfinyl)ethyl]-2-oxoazepan-3-ylcarbamate

溶剂

methanol

water

反应条件

后处理

1. 1
   萃取the mixture was extracted with ethyl acetate
2. 2
   洗涤The organic layer was washed with saturated aqueous sodium carbonate (3×), saturated brine
3. 3
   干燥dried over magnesium sulfate
4. 4
   过滤filtered
5. 5
   浓缩concentrated

实验过程

Sodium periodate (11.3 mg, 0.053 mmol) was added to a solution of tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-1-[2-(methylthio)ethyl]-2-oxoazepan-3-ylcarbamate (22 mg, 0.053 mmol) in methanol (2 mL) and water (2 mL). After 30 min excess sodium periodate (22 mg, 0.11 mmol) was added. After 18 h, saturated aqueous sodium carbonate was added and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium carbonate (3×), saturated brine, dried over magnesium sulfate, filtered and concentrated to give the title compound. MS 431 (M+1).

来源