反应 #481605

反应方程式

3,5-Dimethoxy-4-hydroxy benzaldehyde

ethyl acetoacetate

piperidine—acetic acid

→

title product

Ethyl-alpha-acetyl-3,5-dimethoxy-4-hydroxy-cinnamate

溶剂

benzene

反应条件

后处理

1. 1
   温度at reflux temperature

实验过程

Monodemethylation of 3,4,5-trimethoxy benzaldehyde using sulphuric acid at 40° C. for 8 hours as described above in Example 1 yields syringaldehyde. Condensation of 3,5-Dimethoxy-4-hydroxy benzaldehyde (syringaldehyde) with ethyl acetoacetate in the presence of piperidine—acetic acid and benzene as the reaction medium at reflux temperature yields the title product. The reaction takes about 3.5 hours for completion.

来源