反应 #481601

反应方程式

3,4,5-trimethoxybenzaldehyde

sulphuric acid

→

syringaldehyde

反应条件

后处理

1. 1
   其他at 40° C.
2. 2
   其他for 8 hours

实验过程

Monodemethylation of 3,4,5-trimethoxybenzaldehyde using sulphuric acid at 40° C. for 8 hours as described above in Example 1 yields syringaldehyde. Condensation of 3,5-Dimethoxy-4-hydroxy benzaldehyde (Syringaldehyde) with diethyl malonate in the presence of piperidine—acetic acid and benzene as the reaction medium at reflux temperature under continuous azeotropic water removal yields the title product. The reaction takes about 7.5 hours for completion.

来源