反应 #4816

反应方程式

chloromethyl n-dodecanoate

quinuclidine

KBr

→

n-Dodecanoyloxymethylquinuclidinium Chloride

溶剂

ether

反应条件

后处理

1. 1
   其他to react together at room temperature for 48 hrs
2. 2
   其他the mixture was triturated in anydrous ether overnite
3. 3
   其他The solid was isolated by filtration under a nitrogen atmosphere
4. 4
   洗涤thoroughly washed with anhydrous ether
5. 5
   干燥After drying in vacuo over calcium sulfate at room temperature
6. 6
   其他2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°

实验过程

2.49 g (0.01 mol) chloromethyl n-dodecanoate and 1.12 g (0.01 mol) quinuclidine were mixed and allowed to react together at room temperature for 48 hrs. Anhydrous ether was added to the mixture and the mixture was triturated in anydrous ether overnite. The solid was isolated by filtration under a nitrogen atmosphere and thoroughly washed with anhydrous ether. After drying in vacuo over calcium sulfate at room temperature, 2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°; ir (KBr) 2960, 2930, 1765, 1470, 1120, 1090, 860 and 830 cm-1 ; pmr (CDCl3) δ 5.8 (s, 2H), 3.9 (t, 6H), 2.5 (t, 2H), 2.2 (m, 7H), 1.3 (bs, 18H) and 0.9 (t, 3H) ppm.

来源