反应 #48150

反应方程式

(4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

intermediate 1

(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

3-cyano-4-fluorophenylboronic acid

→

title compound

5-[2-(4,4-Difluoro-piperidine-1-carbonyl)-5-(1-isopropyl-piperidin-4-yloxy)-indol-1-yl]-2-fluoro-benzonitrile

反应条件

后处理

1. 1
   其他In analogy to the procedure described for the synthesis of example 6

实验过程

In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (intermediate 1) and 3-cyano-4-fluorophenylboronic acid. The title compound was obtained in 22% yield as orange oil. MS (m/e): 525.2 (MH+, 100%).

来源