反应 #48122

反应方程式

(4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

intermediate 1

(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

4-fluorobenzyl bromide

→

title compound

(4,4-Difluoro-piperidin-1-yl)-[1-(4-fluoro-benzyl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

反应条件

后处理

1. 1
   其他In analogy to the procedure described for the synthesis of example 1

实验过程

In analogy to the procedure described for the synthesis of example 1, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (intermediate 1) and 4-fluorobenzyl bromide. The title compound was obtained in 5% yield as yellow oil. MS (m/e): 514.3 (MH+, 100%).

来源