反应 #4804

反应方程式

5-cyclopropyl-3-formylamino-methyl-1,2,4-oxadiazole

triethylamine

POCl3

Na2CO3

→

title compound

5-Cyclopropyl-3-isocyanomethyl-1,2,4-oxadiazole

溶剂

CH2Cl2

H2O

反应条件

后处理

1. 1
   workup.ADDITIONwas added
2. 2
   其他was separated
3. 3
   其他dried
4. 4
   其他evaporated in vacuo
5. 5
   workup.ADDITIONThe residue was treated with ether
6. 6
   其他decanted
7. 7
   其他the solution was evaporated

实验过程

A stirred solution of 5-cyclopropyl-3-formylamino-methyl-1,2,4-oxadiazole (60 mmol) and triethylamine (176 mmol) in CH2Cl2 (100 ml) was charged dropwise with POCl3 (60 mmol) at 0° C. The mixture was then left for 30 min. with stirring at 0° C., whereafter a solution of Na2CO3 (60 mmol) in H2O (50 ml) was added. The mixture was heated to room temperature, whereafter the organic phase was separated, dried and evaporated in vacuo. The residue was treated with ether, decanted and the solution was evaporated to give the title compound as an oil.

来源