反应 #479853

ord-206abd35e2754908b10ae8763bb2799f

反应方程式

CC(=O)NC1C(O)OC(CO)C(O)C1O
N-acetylhexosamine
O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO
galactose
OO
hydrogen peroxide
→
O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO
galactose
CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O
N-acetyl-D-galactosamine

反应物

CC(=O)NC1C(O)OC(CO)C(O)C1O
N-acetylhexosamine
—
ferrous
O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO
galactose
OO
hydrogen peroxide
—
N-Acetylhexosamine dialdose

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

N-Acetylhexosamine dialdose may, for example, be manufactured by oxidation of the 6-position of N-acetylhexosamine either chemically or enzymatically. An example of the chemical oxidation is a Fenton method where oxidation is carried out with hydrogen peroxide in the presence of a ferrous salt while that of the enzymatic oxidation is an oxidation using galactose oxidase [EC 1.1.3.9; Cooper, et al.; The Journal of Biological Chemistry, volume 234, pages 445-448 (1959)]. Oxidation of N-acetyl-D-galactosamine with galactose oxidase gives N-acetylgalactosamine dialdose.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06803367B2uspto-grants-2004_10