反应 #47844

反应方程式

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

cyclohexylamine

→

titled compound

收率 24.0%

1-cyclohexylamino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

收率 24.0%

溶剂

THF

反应条件

后处理

1. 1
   其他the solvent was removed under a reduced pressure
2. 2
   其他The resulting residue was purified by flash chromatography

实验过程

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (100 mg, 0.27 mmol) obtained in Example 18 was dissolved in THF (10 mL), and cyclohexylamine (132.86 mg, 0.15 mL, 1.34 mmol) was added dropwise thereto. The mixture was stirred for 12 hrs at RT, and the solvent was removed under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 25 mg of the titled compound (yield: 24%).

来源