反应 #47826

反应方程式

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

ethanol

→

titled compound

收率 52.0%

1-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

收率 52.0%

反应条件

后处理

1. 1
   过滤filtered
2. 2
   其他The organic layer was separated
3. 3
   浓缩concentrated under a reduced pressure
4. 4
   其他The resulting residue was purified by flash chromatography

实验过程

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (30 mg, 0.09 mmol) obtained in Example 18 was dissolved in ethanol (3 mL), silver nitrate (15.50 mg, 0.09 mmol) was added thereto, stirred for 3.5 hrs at RT, and filtered. The organic layer was separated, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 16 mg of the titled compound (yield: 52%).

来源