反应 #47614

反应方程式

lithium hydroxide monohydrate

(S)-2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methylsulfanyl-butyric acid methyl ester

tetrahydrofuran

→

(S)-2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methylsulfanyl-butyric acid

收率 89.0%

溶剂

water

反应条件

后处理

1. 1
   浓缩After such time, the mixture was concentrated in vacuo
2. 2
   其他to remove the tetrahydrofuran
3. 3
   其他The organic layer was separated
4. 4
   干燥dried over sodium sulfate
5. 5
   浓缩concentrated in vacuo

实验过程

A mixture of (S)-2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methylsulfanyl-butyric acid methyl ester (513 mg, 1.44 mmol) in a 1:1 solution of tetrahydrofuran:water (20 mL) was treated with lithium hydroxide monohydrate (120 mg, 2.88 mmol) and stirred for 1.5 h at 25° C. After such time, the mixture was concentrated in vacuo to remove the tetrahydrofuran and partioned between 1N aqueous hydrochloric acid (10 mL) and ethyl acetate (20 mL). The organic layer was separated, dried over sodium sulfate and concentrated in vacuo to afford (S)-2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methylsulfanyl-butyric acid (438 mg, 89%) as a light amber gum.

来源