反应 #474415

反应方程式

Na2SO4

6-(4-aminophenyl)-thiomorpholin-3-one

lithium aluminium hydride

→

title compound

6-(4-aminophenyl)-thiomorpholine

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   过滤The suspension was filtered
2. 2
   洗涤the solids were washed with tetrahydrofuran (2×3 mL)
3. 3
   其他the combined filtrates were evaporated

实验过程

To the solution of 6-(4-aminophenyl)-thiomorpholin-3-one (0.26 g, 1.25 mmol) in anhydrous tetrahydrofuran (6.7 mL) was added lithium aluminium hydride (0.16 g, 4.27 mmol) in several portions and the mixture was stirred at 60° C. for 2 h. Na2SO4×10H2O (2.00 g) was added in small portions until the complex was decomposed. The suspension was filtered, the solids were washed with tetrahydrofuran (2×3 mL) and the combined filtrates were evaporated. The title compound was obtained as a viscous oil (0.25 g, 1.26 mmol, 100%). ESMS m/z 195 (M+H)+.

来源