反应 #4724

反应方程式

Hydrogen peroxide

N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarbothioamide

→

N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

溶剂

ethanol

反应条件

后处理

1. 1
   温度the reaction mixture is briefly heated to boiling
2. 2
   过滤The sulphur which separates is filtered off hot with the aid of active charcoal
3. 3
   浓缩the filtrate is concentrated by evaporation
4. 4
   其他purified by preparative layer chromatography

实验过程

2 ml of 30% Hydrogen peroxide are added to 1.58 g (4 mmol) of N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarbothioamide in 30 ml of ethanol and the reaction mixture is briefly heated to boiling. The sulphur which separates is filtered off hot with the aid of active charcoal and the filtrate is concentrated by evaporation and purified by preparative layer chromatography.

来源