反应 #47109

反应方程式

1-methoxy-2-propanol

ethyl diazoacetate

→

product 473

收率 64.9%

(2-Methoxy-1-methylethoxy)acetic acid ethyl ester

收率 64.9%

溶剂

heptane

dichloromethane

反应条件

后处理

1. 1
   过滤filtered through Celite
2. 2
   其他the filtrate is evaporated
3. 3
   workup.DISTILLATIONdistilled at 133° C.

实验过程

To a solution of 1-methoxy-2-propanol (900 mg, 10.0 mmol) in dichloromethane (20 mL) is added rhodium (II) acetate dimer (10 mg) followed by ethyl diazoacetate (0.95 mL, 9.0 mmol). The reaction mixture is stirred at rt for 30 min. The reaction mixture is diluted with heptane, filtered through Celite, and the filtrate is evaporated and the residue is vacuum distilled at 133° C. to give 1.03 g of the product 473. 1H NMR (CDCl3) δ 4.20 (q, 2H), 3.72 (m, 1H), 3.45 (dd, 1H), 3.37 (dd, 1H), 3.35 (s, 3H), 1.27 (t, 3H), 1.19 (d, 3H).

来源