反应 #47088

反应方程式

cyclohexanol

ethyl diazoacetate

→

product 407

Cyclohexyloxyacetic acid ethyl ester

溶剂

Et2O

dichloromethane

反应条件

后处理

1. 1
   过滤filtered through Celite
2. 2
   其他the filtrate is evaporated
3. 3
   workup.DISTILLATIONdistilled at 150° C.

实验过程

To a solution of cyclohexanol (1.0 g, 0.95 mmol) in dichloromethane (30 mL) is added rhodium (II) acetate dimer (44 mg) followed by ethyl diazoacetate (1.14 g, 10.0 mmol). The reaction mixture is stirred at RT for 20 min. The reaction mixture is diluted with Et2O, filtered through Celite, and the filtrate is evaporated and the residue is vacuum distilled at 150° C. to give 1.57 g of the product 407. 1H NMR (CDCl3) δ 4.23 (q, 2H), 4.10 (s, 2H), 3.33 (m, 1H), 1.93 (m, 2H), 1.74 (m, 2H), 1.54 (m, 1H), 1.4-1.1 (m, 8H)

来源