反应 #47067

反应方程式

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

2,5-dichlorobenzyl chloride

→

product 238

收率 49.6%

2-[(2,5-Dichlorobenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

收率 49.6%

溶剂

EtOH

反应条件

后处理

1. 1
   其他evaporated to dryness
2. 2
   过滤The insoluble material is filtered

实验过程

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2,5-dichlorobenzyl chloride (327 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 175 mg of the product 238. 1H NMR (DMSO-d6) δ 11.50 (s, 2 H), 8.00 (s, 1 H), 7.70-7.50 (m, 2 H), 7.20-7.00 (m, 6 H), 6.95-6.80 (m, 4 H), 5.81 (s, 2 H), 4.90 (s, 2 H); MS: m/z 413 (M++1).

来源