反应 #470443

反应方程式

5-bromo-2-methylpyrimidine

NBS

dibenzoyl peroxide

→

5-Bromo-2-(bromomethyl)pyrimidine

收率 48.0%

溶剂

tetrachloromethane

反应条件

后处理

1. 1
   温度was refluxed for 36 h
2. 2
   其他The solvent was removed in vacuo
3. 3
   其他the residue was purified by column chromatography on silica gel (ethyl acetate in petroleum ether, 1% v/v)

实验过程

A mixture of 5-bromo-2-methylpyrimidine (100 mg, 0.58 mmol), NBS (103 mg, 0.58 mmol), dibenzoyl peroxide (10 mg, 0.04 mmol) in tetrachloromethane (10 mL) was refluxed for 36 h. The solvent was removed in vacuo and the residue was purified by column chromatography on silica gel (ethyl acetate in petroleum ether, 1% v/v) to give 5-Bromo-2-(bromomethyl)pyrimidine (70 mg, 48%) as a white solid. 1HNMR (400 MHz, CDCl3) δ 4.49 (s, 2H), 8.72 (s, 2H).

来源