反应 #470442

反应方程式

water

2-amino-5-bromopyridine

pyridine

acetic anhydride

→

title compound

收率 93.0%

N-(5-bromopyridin-2-yl)acetamide

收率 93.0%

溶剂

THF

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate (3×30 mL)
2. 2
   洗涤The combined organic layers were washed with saturated aqueous NaHCO3 and brine
3. 3
   干燥dried over Na2SO4
4. 4
   浓缩concentrated

实验过程

To a solution of 2-amino-5-bromopyridine (0.50 g, 2.9 mmol) in THF (10 mL) was added pyridine (343 mg, 4.3 mmol) and acetic anhydride (295 mg, 2.9 mmol) at room temperature and stirred overnight. To the mixture water (30 mL) was added, extracted with ethyl acetate (3×30 mL). The combined organic layers were washed with saturated aqueous NaHCO3 and brine, dried over Na2SO4, concentrated to give the title compound (0.58 g, 92%) as a white solid LCMS: 215 [M+2]+; 1HNMR (400 MHz, DMSO-d6) δ 2.09 (s, 3H), 7.97 (dd, J=8.8, 2.4 Hz, 1H), 8.06 (d, J=8.8 Hz, 1H), 8.41 (d, J=1.2 Hz, 1H), 10.64 (s, 1H).

来源