反应 #470440

反应方程式

5-Bromo-2-ethylpyrimidine-4-carboxylic acid

→

compound 0601-121

收率 38.0%

5-Bromo-2-ethylpyrimidine

收率 38.0%

溶剂

xylene

反应条件

后处理

1. 1
   温度was refluxed for 2 h
2. 2
   温度After cooling
3. 3
   洗涤was eluted with petroleum ether

实验过程

A mixture of 5-Bromo-2-ethylpyrimidine-4-carboxylic acid (5.6 g, 24.3 mmol) in xylene (50 mL) was refluxed for 2 h. After cooling, the mixture was applied directly to a silica column, which was eluted with petroleum ether, then ethyl acetate in petroleum ether (5%) to give compound 0601-121 (1.7 g, 38%) as a yellow liquid. 1H NMR (400 MHz, DMSO-d6): 1.26 (t, J=7.6 Hz, 3H), 2.87 (q, J=7.6 Hz, 2H), 8.90 (s, 2H).

来源