反应 #470416

反应方程式

water

Benzylamine

3′,7-Dihydroxyisoflav-3-ene

ethanol

formaldehyde

→

title compound

3-(3-Benzyl-2,3,4,8-tetrahydrochromeno[6,7-e][1,3]oxazin-7-yl)phenol

反应条件

后处理

1. 1
   其他Reaction mixture
2. 2
   萃取then extracted with ethyl acetate (3×30 ml)
3. 3
   其他chromatographed

实验过程

3′,7-Dihydroxyisoflav-3-ene (100 mg, 0.42 mmol) was dissolved in ethanol (4 ml). Benzylamine (0.14 ml, 1.28 mmol) was added followed by formaldehyde solution (0.42 ml, 5.59 mmol, 37% wt.). The reaction was stirred at room temperature for 1 day. Reaction mixture was poured into water (50 ml) then extracted with ethyl acetate (3×30 ml) and the combined organic layers reduced. The solid was flash chromatographed using 100% dichloromethane. Fractions 6-12 were combined and reduced to afford the title compound.

来源