反应 #470409

反应方程式

BuLi

hexamethyldisilazane

NH4Cl

→

lithiumhexamethyl disilazide

溶剂

—

hexanes

THF

THF

反应条件

后处理

1. 1
   workup.STIRRINGThe mixture subsequently stirred at −70° C. for an additional hr
2. 2
   萃取extracted with ethyl acetate

实验过程

A solution of lithiumhexamethyl disilazide was prepared by adding 4.8 ml of 1.6 m BuLi in hexanes to a solution of 1.8 ml of hexamethyldisilazane in 10 ml of dry THF at −40° C. This solution was stirred for 15 min at −40° C. A quantity of 7.8 ml of this solution was added dropwise to a solution of 1.34 g of compound 13 in 20 ml of dry THF at −70° C. The mixture subsequently stirred at −70° C. for an additional hr and then poured into 50 ml of sat. NH4Cl solution and extracted with ethyl acetate.

来源