反应 #470392

反应方程式

2,6-diisopropylaniline

2-fluoronitrobenzene

potassium fluoride

→

desired product

收率 47.9%

2,6-diisopropyl-N-(2-nitrophenyl)aniline

收率 47.9%

溶剂

water

反应条件

后处理

1. 1
   温度After cooled to room temperature
2. 2
   萃取The mixture was then extracted with dichloromethane (200 mL) for three times
3. 3
   其他The solvent was evaporated
4. 4
   其他the residue was purified by column chromatography

实验过程

2,6-diisopropylaniline (25 g, 141 mmol), 2-fluoronitrobenzene (10 g, 70 mmol), and potassium fluoride (6.2 g, 106 mmol) were mixed in a one-neck flask. The mixture was heated up to 180° C. under nitrogen for 48 hours. After cooled to room temperature, water (200 mL) was added. The mixture was then extracted with dichloromethane (200 mL) for three times. The solvent was evaporated and the residue was purified by column chromatography using 20% of dichloromethane in hexanes. 10 g of desired product was obtained.

来源