反应 #470387

反应方程式

N1-phenylbenzene-1,2-diamine

benzaldehyde

→

desired product

收率 37.0%

1,2-diphenyl-1H-benzo[d]imidazole

收率 37.0%

溶剂

methoxylethanol

反应条件

后处理

1. 1
   温度The mixture was heated up
2. 2
   温度to reflux for 48 hours
3. 3
   其他the solvent was evaporated
4. 4
   其他The residue was purified by column chromatography

实验过程

N1-phenylbenzene-1,2-diamine (4.15 g, 22 mmol) and benzaldehyde (2.1 g, 20 mmol) were mixed with methoxylethanol (60 ml) in a three-neck flask. The mixture was heated up to reflux for 48 hours. After cooled to room temperature, the solvent was evaporated. The residue was purified by column chromatography using dichloromethane to 5% of ethyl acetate in dichloromethane as eluent. 2 g of desired product was obtained.

来源