反应 #470381

反应方程式

L-lysine methyl ester dihydrochloride

triethylamine

benzyloxy acetyl chloride

→

2

收率 31.8%

2,6-Bis-(2-benzyloxy-acetylamino)-hexanoic acid methyl ester

收率 31.8%

溶剂

ethyl acetate

反应条件

后处理

1. 1
   过滤The solids were filtered off
2. 2
   洗涤The organic phase was washed with 5% sodium bicarbonate (2×100 mL), water (2×100 mL)
3. 3
   干燥dried over sodium sulphate
4. 4
   workup.DISTILLATIONdistilled
5. 5
   其他The crude 2 was purified by column chromatography on silica gel

实验过程

To a mixture of L-lysine methyl ester dihydrochloride (50 grams, 214.4 mmol), triethylamine (131 grams, 1.294 moles) in ethyl acetate (750 mL) at room temperature was added benzyloxy acetyl chloride (120 grams, 650.4 mmol) drop wise. The mixture was further stirred at room temperature for 2 hours. The solids were filtered off. The organic phase was washed with 5% sodium bicarbonate (2×100 mL), water (2×100 mL), dried over sodium sulphate and distilled. The crude 2 was purified by column chromatography on silica gel using Benzene: Ethyl acetate (9:1) to get pure 2 (30 grams, 31.8%) as a white powder.

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