反应 #470359

反应方程式

N-methylpyrrolidine

Chloromethyl methyl ether

→

desired product

N-Methyl-N-Methoxymethylpyrrolidinium Chloride

溶剂

toluene

反应条件

后处理

1. 1
   温度gradually heated to a higher temperature
2. 2
   workup.STIRRINGstirred at room temperature for 10 hours
3. 3
   其他the reaction
4. 4
   过滤The reaction mixture was filtered
5. 5
   洗涤the resulting solid product was washed with 150 g of toluene and 150 g of acetone
6. 6
   其他The washed product was dried in a vacuum

实验过程

A 30.0 g quantity of N-methylpyrrolidine (reagent, product of Tokyo Kasei Co., Ltd.) was dissolved in 120 g of toluene, followed by replacement with nitrogen. Chloromethyl methyl ether (31.2 g, reagent, product of Tokyo Kasei Co., Ltd.) was added dropwise to the solution at 5° C. over a period of 1 hour. The mixture was stirred at 5° C. for 1 hour, then gradually heated to a higher temperature, and stirred at room temperature for 10 hours to complete the reaction. The reaction mixture was filtered, and the resulting solid product was washed with 150 g of toluene and 150 g of acetone. The washed product was dried in a vacuum to obtain 53.7 g of the desired product (white solid).

来源