反应 #46904

反应方程式

4-hydroxybenzamide

diclofenac

hydroxybenzotriazole

DCC

→

4-carbamoylphenyl 2-[2-(2,6-dichlorophenylamino)-phenyl]acetate

收率 17.0%

溶剂

chloroform

N,N-dimethylformamide

反应条件

后处理

1. 1
   workup.STIRRINGstirred for 1 h at 0° C.
2. 2
   其他at room temperature
3. 3
   过滤After filtration
4. 4
   其他the filtrate was evaporated under reduced pressure
5. 5
   其他the oily residue thus obtained
6. 6
   洗涤the organic layer was washed with brine
7. 7
   干燥dried on anhydrous MgSO4
8. 8
   过滤filtered
9. 9
   其他the solvent evaporated
10. 10
    洗涤eluted with CH2Cl2/MeOH (9/1), from which 4-carbamoylphenyl 2-(2-(2,6-dichlorophenylamino)phenyl)acetate (5)
11. 11
    其他was obtained (212 mg, 17% yield)

实验过程

To the solution of 1 (diclofenac, 890 mg, 3.0 mmol) in 50 mL of N,N-dimethylformamide, hydroxybenzotriazole (445 mg, 3.3 mmol) and DCC (680 mg, 3.3 mmol) were added with stirring at 0° C. for 1 h. To the reaction mixture 4-hydroxybenzamide (4, 616 mg, 4.5 mmol) was added and stirred for 1 h at 0° C. and 3 hs at room temperature. After filtration, the filtrate was evaporated under reduced pressure and the oily residue thus obtained was dissolved in chloroform; the organic layer was washed with brine, dried on anhydrous MgSO4, filtered and the solvent evaporated. The crude product 5 was loaded on a silica gel open column and eluted with CH2Cl2/MeOH (9/1), from which 4-carbamoylphenyl 2-(2-(2,6-dichlorophenylamino)phenyl)acetate (5) was obtained (212 mg, 17% yield).

来源