反应 #46768

反应方程式

2-bromo-phenethylamine

triethylamine

menthoyl chloride

→

oil

收率 98.3%

2-Isopropyl-5-methyl-cyclohexanecarboylic acid [2-(2-bromo-phenyl)-ethyl]-amide

收率 98.3%

溶剂

CH2Cl2

CH2Cl2

反应条件

后处理

1. 1
   其他A 100 mL round bottom flask equipped with a stir bar
2. 2
   洗涤washed with water (3×100 mL)
3. 3
   干燥Organic layer was dried over anhydrous sodium sulfate
4. 4
   浓缩concentrated under reduced pressure

实验过程

A 100 mL round bottom flask equipped with a stir bar was charged with CH2Cl2 (30 mL), 2-bromo-phenethylamine (1.0 g, 5.00 mmol) and triethylamine (684 μl, 5.05 mmol). The reaction solution was treated with menthoyl chloride (1.02 g, 5.05 mmol) in one portion and stirred at ambient temperature for 30 minutes. The reaction was diluted with CH2Cl2 (50 mL) and washed with water (3×100 mL). Organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a thick oil (1.8 g). Product was used for next step without purification.

来源