反应 #46725

反应方程式

HCl

N-(2,4-dihydroxy phenyl)-2,2,2-trifluoro-acetamide

K2CO3

1-bromooctane

→

black solid

收率 82.5%

N-(2-Hydroxy-4-octyloxy-phenyl)-2,2,2-trifluoro-acetamide

收率 82.5%

溶剂

DMF

反应条件

后处理

1. 1
   萃取extracted with diethylether (30 mL)
2. 2
   干燥The organic phase was dried (MgSO4)
3. 3
   过滤filtered
4. 4
   其他the eluate evaporated

实验过程

To a solution of N-(2,4-dihydroxy phenyl)-2,2,2-trifluoro-acetamide (0.44 g; 2 mmol) in DMF (4 mL) was added K2CO3 and 1-bromooctane (0.37 mL; 2.1 mmol). The slurry was stirred for 2 days at room temperature, poured onto 0.1 M HCl (aq.; 50 mL) and then extracted with diethylether (30 mL). The organic phase was dried (MgSO4), filtered and the eluate evaporated to leave 550 mg of black solid which was purified by chromatography (SiO2; PE80-100° C./EtOAc=4:1) to leave 100 mg (15%) of a pure white solid. Mp. 114-116° C.; MS (GC-MS; Cl): 334 (MH+).

来源