反应 #465937

反应方程式

isatin

HCl

→

acridine acid

溶剂

KOH

water

反应条件

后处理

1. 1
   温度The solution was cooled
2. 2
   过滤filtered after 1 h
3. 3
   洗涤washed with water
4. 4
   其他The solid was air-dried over night
5. 5
   洗涤washed with CH2Cl2
6. 6
   其他air-dried

实验过程

The isatin product from step (a) was refluxed in 300 mL of 10% KOH solution in water for ca. 48 h. The solution was cooled and acidified to pH 2-3 with HCl. The yellow solid was suction filtered after 1 h and then washed with water. The solid was air-dried over night, washed with CH2Cl2 and then air-dried yielding 23.76 g of the acridine acid. 1H NMR (DMSO-d6) δ 7.72-8.30 (m, 7H).

来源