反应 #464637

ord-3460eac4daee4552984a4f54f9e2b7da

反应方程式

COC(=O)[C@@H](N)Cc1c[nH]c2ccccc12
racemic tryptophan methyl ester
Cc1ccc(C=O)s1
5-methyl-2-thiophenecarboxaldehyde
→
COC(=O)C1Cc2c([nH]c3ccccc23)C(c2ccc(C)s2)N1
title compound
COC(=O)C1Cc2c([nH]c3ccccc23)C(c2ccc(C)s2)N1
Methyl 1,2,3,4-tetrahydro-1-(5-methyl-2-thienyl)-9H-pyrido [3,4-b]indole-3-carboxylate

反应物

COC(=O)[C@@H](N)Cc1c[nH]c2ccccc12
racemic tryptophan methyl ester
Cc1ccc(C=O)s1
5-methyl-2-thiophenecarboxaldehyde

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

The same method but starting from racemic tryptophan methyl ester and 5-methyl-2-thiophenecarboxaldehyde gave the cis and trans isomers of the title compound.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06025494uspto-grants-2000_02