反应 #463607

反应方程式

(2-dimethylaminoethyl)sulfamoyl chloride

1,2-O-dioleylglycerol

→

title compound

收率 18.3%

3-O-(2-dimethylaminoethyl)sulfamoyl-1,2-O-dioleylglycerol

收率 18.3%

溶剂

methylene chloride

methylene chloride pyridine

反应条件

后处理

1. 1
   其他After completion of the reaction
2. 2
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
3. 3
   workup.ADDITIONthe residue was treated with methylene chloride-saturated aqueous sodium hydrogen carbonate solution
4. 4
   干燥The methylene chloride layer was dried over sodium sulfate
5. 5
   浓缩concentrated under reduced pressure

实验过程

In 4 ml of methylene chloride-pyridine (2:1) was dissolved 150 mg (0.25 mmol) of 1,2-O-dioleylglycerol. Then, 1 ml of a solution of 150 mg (0.75 mmol) (2-dimethylaminoethyl)sulfamoyl chloride in methylene chloride was added and the reaction was carried out at ambient temperature for 2 hours. After completion of the reaction, the solvent was distilled off under reduced pressure and the residue was treated with methylene chloride-saturated aqueous sodium hydrogen carbonate solution. The methylene chloride layer was dried over sodium sulfate and concentrated under reduced pressure. The residue was subjected to column chromatography (silica gel/methylene chloride-methanol) to provide 34 mg (18%) of the title compound of the invention.

来源