反应 #461795

反应方程式

ammonium peroxodisulfate

2-chloro-4,5-difluorobenzophenone

sulfuric acid

→

2-chloro-4,5-difluorobenzoic acid

收率 80.8%

溶剂

acetic acid

反应条件

后处理

1. 1
   温度the mixture is heated for 2 h at 150° C
2. 2
   过滤Dilution with 200 g of water and filtration

实验过程

8 g of ammonium peroxodisulfate are introduced into 5 g (19.8 mmol ) of 2-chloro-4,5-difluorobenzophenone and 20 g of glacial acetic acid and the mixture is heated at 90° C. (12 h). 100 g of 70% sulfuric acid are then added and the mixture is heated for 2 h at 150° C. Dilution with 200 g of water and filtration gives 3.1 g (16.0 mmol, 81%) of 2-chloro-4,5-difluorobenzoic acid (purity (GC) ca. 92%). Recrystallization from water gives 2.5 g of product melting at 104° C.-105° C.

来源