反应 #46060

反应方程式

sodium bicarbonate

neopentyl glycol

1,3-dichloroacetone

benzene

→

2,2-bis-chloromethyl-5,5-dimethyl-1,3-dioxolane

收率 34.6%

溶剂

water

—

hexanes

反应条件

后处理

1. 1
   其他This compound was synthesized
2. 2
   干燥The organic layer was dried over anhydrous magnesium sulfate
3. 3
   浓缩concentrated in vacuo

实验过程

This compound was synthesized by substantially following the procedure of the above-mentioned article by Isaka, Ejiri, and Nakamura. 69 grams of neopentyl glycol, 76 grams of 1,3-dichloroacetone, 50 ml of benzene, and 2.3 g of p-toluenesulfonic acid were refluxed through a Dean-Stark water separator for 8 hours whereon the reaction was diluted with hexanes and neutralized with aqueous sodium bicarbonate. The organic layer was dried over anhydrous magnesium sulfate and concentrated in vacuo yielding 41.2 g of 2,2-bis-chloromethyl-5,5-dimethyl-1,3-dioxolane, a pale yellow liquid.

来源