反应 #45926

反应方程式

2,4-difluoronitrobenzene

Et3N

n-butylamine

→

2-n-butylamino-4-fluoronitrobenzene

溶剂

DMF

DMF

反应条件

后处理

1. 1
   其他The reaction was quenched by cold H2O (100 mL)
2. 2
   萃取the resulting mixture was extracted with EtOAc (4×100 mL)
3. 3
   洗涤The combined EtOAc extracts were washed with brine (3×60 mL)
4. 4
   干燥dried (anhydrous Na2SO4)
5. 5
   其他The solvent was removed in vacuo

实验过程

To a stirred solution of 2,4-difluoronitrobenzene (50 mmol), Et3N (100 mmol) and DMF (80 mL) was added dropwise a solution of n-butylamine (51 mmol) in DMF (20 mL) at rt, and the mixture was stirred at rt for 5 h. The reaction was quenched by cold H2O (100 mL), and the resulting mixture was extracted with EtOAc (4×100 mL). The combined EtOAc extracts were washed with brine (3×60 mL) and dried (anhydrous Na2SO4). The solvent was removed in vacuo to afford the desired 2-n-butylamino-4-fluoronitrobenzene which was used for further transformation.

来源