反应 #4584

反应方程式

2-(2-propanon-1-yloxy)phenylsulfonamide

ethylene glycol

p-toluenesulfonic acid

toluene

→

2-(2-methyl-1,3-dioxolan-2-yl-methoxy)phenylsulfonamide

溶剂

ethyl acetate

反应条件

后处理

1. 1
   温度is heated for 7 hours
2. 2
   温度to reflux
3. 3
   其他while simultaneously separating
4. 4
   其他the water of reaction
5. 5
   洗涤the organic phase is washed with saturated sodium bicarbonate solution and water
6. 6
   其他dried
7. 7
   浓缩concentrated

实验过程

A mixture of 4.58 g of 2-(2-propanon-1-yloxy)phenylsulfonamide, 2 ml of ethylene glycol, 0.02 g of p-toluenesulfonic acid and 30 ml of toluene is heated for 7 hours to reflux while simultaneously separating the water of reaction. The cooled solution is taken up in 80 ml of ethyl acetate and the organic phase is washed with saturated sodium bicarbonate solution and water, dried and concentrated, affording 5 g of 2-(2-methyl-1,3-dioxolan-2-yl-methoxy)phenylsulfonamide in the form of a yellow viscous oil which can be further used without purification.

来源