反应 #4565

反应方程式

3-chloro-4-fluoroaniline

pyridine

2-chloroacetyl chloride

→

N-(2-chloroacetyl)-3-chloro-4-fluoroaniline

收率 88.0%

溶剂

toluene

反应条件

后处理

1. 1
   温度The resulting solution was cooled to ca 0° C.
2. 2
   workup.STIRRINGThe reaction mixture was stirred at room temperature for 5 hours
3. 3
   萃取it was extracted twice with 100 ml
4. 4
   干燥The resulting toluene solution was dried
5. 5
   浓缩it was concentrated in vacuo
6. 6
   其他to give 32.6 g

实验过程

To 130 ml. of toluene was added, with stirring, 24.0 g. (0.165 mole) of 3-chloro-4-fluoroaniline and 13.5 ml. (0.166 mole) of pyridine. The resulting solution was cooled to ca 0° C. and 13.2 ml. (0.166 mole) of 2-chloroacetyl chloride was added. The reaction mixture was stirred at room temperature for 5 hours and then it was extracted twice with 100 ml. of 1N hydrochloric acid, followed by 100 ml. of saturated sodium chloride solution. The resulting toluene solution was dried using magnesium sulfate, and then it was concentrated in vacuo to give 32.6 g. (88% yield) of N-(2-chloroacetyl)-3-chloro-4-fluoroaniline.

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