反应 #45582

反应方程式

4-amino-6-bromo-5-hydroxy-2-methylbiphenyl-3-carbonitrile

ethyl acetate

diisopropylethylamine

ethyl acetate

Cyclopropanecarbonyl chloride

→

2-bromo-5-cyano-4-(cyclopropanecarbonylamino)-6-methylbiphenyl-3-yl cyclopropanecarboxylate

反应条件

后处理

1. 1
   温度by cooling in an ice-water bath
2. 2
   其他with restoring to room temperature
3. 3
   其他The reaction liquid
4. 4
   洗涤washed with saturated brine
5. 5
   干燥dried over anhydrous magnesium sulfate
6. 6
   浓缩concentrated under reduced pressure
7. 7
   其他The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=5:1)

实验过程

Under nitrogen atmosphere, 4-amino-6-bromo-5-hydroxy-2-methylbiphenyl-3-carbonitrile (I-42) (150 mg, 0.495 mmol) was dissolved in ethyl acetate (6 ml), diisopropylethylamine (431 μl, 2.48 mmol) was added, followed by cooling in an ice-water bath. Cyclopropanecarbonyl chloride (112 μl, 1.24 mmol) was dropwise added to it, followed by stirring overnight with restoring to room temperature. The reaction liquid was diluted with ethyl acetate, washed with saturated brine, then dried over anhydrous magnesium sulfate, concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=5:1) to obtain 2-bromo-5-cyano-4-(cyclopropanecarbonylamino)-6-methylbiphenyl-3-yl cyclopropanecarboxylate (87 mg) and a mixture of (2-bromo-5-cyano-3-hydroxy-6-methylbiphenyl-4-yl)cyclopropanecarboxamide and 4-amino-2-bromo-5-cyano-6-methylbiphenyl-4-yl cyclopropanecarboxylate (110 mg). Subsequently, 2-bromo-5-cyano-4-(cyclopropanecarbonylamino)-6-methylbiphenyl-3-yl cyclopropanecarboxylate was dissolved in ethanol (30 ml), aqueous 0.1 N sodium hydroxide solution (5.94 ml) was added, followed by stirring overnight at room temperature. Ethanol was evaporated away under reduced pressure, then the residue was dissolved in ethyl acetate, followed by successively washing with 1 N hydrochloric acid, saturated brine, dried on anhydrous magnesium sulfate, concentrated under reduced pressure to obtain (2-bromo-5-cyano-3-hydroxy-6-methylbiphenyl-4-yl)cyclopropanecarboxamide (56 mg) as a colorless oil.

来源