反应 #45579

反应方程式

N-iodosuccinimide

acetic acid

4-bromo-3-fluoro-2-methoxy-5-methylaniline

→

4-Bromo-3-fluoro-6-iodo-2-methoxy-5-methylphenylamine

溶剂

brine

反应条件

后处理

1. 1
   萃取followed by extraction twice with ethyl acetate
2. 2
   洗涤the organic layer was washed three times with saturated brine
3. 3
   干燥dried over anhydrous magnesium sulfate

实验过程

N-iodosuccinimide (1.91 g, 8.5 mmol) was added to an acetic acid (40 ml) solution of 4-bromo-3-fluoro-2-methoxy-5-methylaniline (I-43) (1.90 g, 8.1 mmol), followed by stirring at room temperature for 67 hours. Saturated brine was added to the reaction liquid, followed by extraction twice with ethyl acetate, the organic layer was washed three times with saturated brine, dried over anhydrous magnesium sulfate.

来源