反应 #455509

反应方程式

6-[2-(1H-imidazole-4-yl)-ethoxy]-3,4-dihydro-2H-naphthalen-1-one, monohydrochloride

5-methyl-2-thiophene carboxaldehyde

→

title compound

收率 53.1%

6-[2-(1H-Imidazole-4-yl)-ethoxy]-2-(5-methyl-thiophen-2-ylmethylene)-3,4-dihydro-2H-naphthalen-1-one

收率 53.1%

溶剂

KOH

EtOH

反应条件

实验过程

According to the method of Example 34, 6-[2-(1H-imidazole-4-yl)-ethoxy]-3,4-dihydro-2H-naphthalen-1-one, monohydrochloride (0.313 g, 1.07 mmol) was reacted with 5-methyl-2-thiophene carboxaldehyde (0.142 g, 1.13 mmol) in 5 mL of 4% KOH in EtOH overnight to afford 0.207 g (44%) of the title compound as a bright orange solid, mp 69-70° C.: CI-MS m/e 364 (M+), 365 (M+ +1).

来源