反应 #45521

反应方程式

N-(4-{4-amino-7-[(1E)-3-oxoprop-1-enyl]thieno [3,2-c]pyridin-3-yl}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide

methyl hydrazine

→

title compound

N-{4-[4-amino-7-(1-methyl-4,5-dihydro-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-3-yl]-2-methoxyphenyl}-1-methyl-1H-indole-2-carboxamide

溶剂

water

反应条件

后处理

1. 1
   过滤the white precipitate was collected by filtration
2. 2
   其他dried

实验过程

N-(4-{4-amino-7-[(1E)-3-oxoprop-1-enyl]thieno [3,2-c]pyridin-3-yl}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide (0.I0 g, 0.207 mmol) was stirred with methyl hydrazine (0.5 mL) at ambient temperature for 3 hours then water (8 mL) was added and the white precipitate was collected by filtration and dried to give the title compound. Rt=3.62 min (Conditions a) MS m/e: 511 (M+H)30, 509 (M−H)31 .

来源