反应 #4529

反应方程式

α-chloroethyl furfuryl carbonate

ethyl glycinate

water

NaCl

→

expected product

收率 66.0%

ethyl furfuryloxycarbonyl-glycinate

收率 66.0%

溶剂

THF

potassium carbonate

反应条件

后处理

1. 1
   温度maintained at between 5° and 10° C
2. 2
   其他to come to room temperature
3. 3
   萃取the mixture is extracted with 3×40 ml of ethyl ether
4. 4
   干燥dried over magnesium sulphate

实验过程

2.05 g (10 mmol) of α-chloroethyl furfuryl carbonate are added to a solution of 1.03 g (10 mmol) of ethyl glycinate in 6 ml of THF and 4 ml of 0.5M potassium carbonate solution maintained at between 5° and 10° C. The mixture is allowed to come to room temperature and is stirred for 18 hours. 50 ml of water saturated with NaCl are added and the mixture is extracted with 3×40 ml of ethyl ether. The organic phases are combined and dried over magnesium sulphate. After removal of the solvent and distillation, 1.5 g (66% yield) of the expected product is collected.

来源