反应 #45258

反应方程式

SnCl2.2H2O

3-bromo-phenylamine

NaNO2

→

(3-bromo-phenyl)-hydrazine

溶剂

HCl

HCl

反应条件

后处理

1. 1
   workup.STIRRINGThe reaction solution was stirred for an additional 2 h at RT
2. 2
   过滤The precipitate was filtered
3. 3
   洗涤washed with ethanol and ether

实验过程

To a solution of 3-bromo-phenylamine (17 g, 0.1 mol) in concentrated HCl (200 mL) was added an aqueous solution (20 mL) of NaNO2 (7 g, 0.1 mol) at 0° C. and the resulting mixture was stirred for 1 h. A solution of SnCl2.2H2O (45 g, 0.2 mmol) in concentrated HCl (500 mL) was then added at 0° C. The reaction solution was stirred for an additional 2 h at RT. The precipitate was filtered and washed with ethanol and ether to give (3-bromo-phenyl)-hydrazine as a white solid, which was used for the next reaction without further purification

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