反应 #452487

反应方程式

1-(2-Quinolylcarbonyl)piperazine hydrochloride

sodium hydroxide

→

title compound

收率 79.1%

1-(2-quinolylcarbonyl)piperazine

收率 79.1%

溶剂

water

反应条件

后处理

1. 1
   萃取The resulting mixture was extracted with chloroform
2. 2
   洗涤the extract was washed with an aqueous solution of sodium chloride
3. 3
   干燥dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONThe solvent was distilled off

实验过程

1-(2-Quinolylcarbonyl)piperazine hydrochloride (6.18 g, 22.2 mmol) was dissolved in water. The thus-obtained solution was rendered basic with a concentrated aqueous solution of sodium hydroxide. The resulting mixture was extracted with chloroform, and the extract was washed with an aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was distilled off, whereby 4.236 g of the title compound were obtained as a colorless oil (yield: 79.1%).

来源